摘要
干细胞因子(stemcellfactor,SCF)是酪氨酸激酶受体的配体。哺乳动物卵巢组织能表达SCF,它不仅能促进和诱导卵母细胞的发育,并能调控卵泡细胞间的相互作用及激素的生成,而且是卵泡发育过程中重要的旁分泌因子,可能激活蛋白激酶C(PKC)和有丝分裂原激活蛋白激酶的激酶(MEK)及PI3激酶途径信号分子等信号途径,对卵泡发育起调节作用。
Stem cell factor （SCF） is the ligand of tyrosine kinase receptor （c-Kit）. SCF is produced by ovary organs. SCF is essential for follicular development, especially the early development of follicles. It also activate the expression of steroid hormone in ovaries and the signaling pathways between follicular cells. And, SCF maybe regulate the follicular development through inactivating the PKC, MEK pathways and PI3 pathway.
出处
《细胞生物学杂志》
CSCD
2006年第5期667-670,共4页
Chinese Journal of Cell Biology
基金
江苏省自然科学基金资助项目(No.BK2003075)~~
关键词
干细胞因子
卵泡发育
信号转导
stem cell factor
follicle development
signaling pathway
