摘要
目的:探讨肾性高血压大鼠心肌组织和血浆血管紧张素Ⅱ(AngⅡ)和醛固酮(Ald)的变化对心肌肥厚和心功能的影响,并观察AngⅡ受体拮抗剂缬沙坦对心肌肥厚和心功能的治疗作用。方法:34只SD大鼠分为缬沙坦治疗组(13只,V组),非缬沙坦治疗组(11只,NV组)和假手术组(10只,S组)。V组和NV组在左肾动脉置入内径为0·3mm的银夹(2K1C)。术后2周,V组每天给予缬沙坦30mg/kg,一次性灌胃治疗;S组和NV组每天给予相同容量的饮用水灌胃,共10周。观察各组大鼠的血压、心脏结构、心肌收缩功能、血浆和心肌中AngⅡ、Ald的变化。结果:①各组间治疗前体重、尾动脉收缩压、左室质量(LVM)、相对室壁厚度(RWT)、左室射血分数(LVEF)、短轴缩短率(FS)、中层短轴缩短率(mFS)、室壁应力(MESS)均差异无统计学意义(均P>0·05);②NV组术后第10周尾动脉收缩压、RWT、LVM、LVM指数(LVMI)较S组和V组均明显增加,而左室舒张末期内径(LVDd)明显减小,差异有统计学意义(均P<0·01)。V组高于S组,但差异无统计学意义(均P>0·05);③NV组的LVEF、MESS、mFS、实测mFS/预测mFS明显小于S组和V组(均P<0·05),V组和S组比较差异无统计学意义(P>0·05);④V组和NV组大鼠血浆AngⅡ明显高于S组(均P<0·01),V组和NV组比较差异无统计学意义(P>0·05);⑤血浆Ald各组比较差异无统计学意义(P>0·05),心肌组织Ald NV组与V组比较差异差异有统计学意义(P<0·05),但与S组比较无统计学意义。结论:①2K1C大鼠可产生明确的肾素增高所致的高血压左室肥厚和心功能不全;②Ald与高血压左室肥厚和几何构型及其心力衰竭发展密切相关;③缬沙坦可抑制左室肥厚和收缩功能不全的发生发展。
Objective：To evaluate the effects of the variation of angiotensin Ⅱ （Ang Ⅱ ） and Aldosteron （ALD） in plasma and myocardium of the goldblatt rats on the left ventricular hypertrophy and cardica function and Ang Ⅱ receptor antagonist valsartan interventional treatment. Method： Thirty-four male SD rats were divided into three groups： valsartan treated （ n = 13, V group）, non-valsartan treated （ n = 11, NV group）and sham operation （ n = 10,S group）. V and NV groups were implanted a silver clip with 0.3 mm lumen in the left renal artery. V group was given Valsartan at the dose of 30 mg · kg^- 1 · d ^-1 by gastric fed. S and NV groups were given water served as controls. All the groups were treated for a total of 10 weeks and blood pressure, wall thicknesses and Ang Ⅱ , ALD in plasma and myocardium were measured. Result：①The differences of body weight, tail systolic pressure, left ventricular mass （LVM）, relative wall thickness （RWT）, left ventricular eject fraction （LVEF）, fractional shortening （FS）, middle-level fractional shortening （mFS） and meridional end-systolic wall stress （MESS） were insignificant statistically among all the groups before treatment （P 〉0.05）. ②Tail systolic pressure, RWT, LVM and left ventricular mess index （LVMI） in NV group increased and left ventricular end-diastolic diameter （LVDd） decreased significantly than S and V groups （ P 〈0.01）. In this procedure, V group was higher than S group, but the difference was statistically insignificant. ③LVEF, MESS, mFS, and observed/predicted mFS in NV group were significantly lower than S and V groups （ P 〈0. 05）. There was no significant difference between V and S groups （ P 〉0. 05）. ④Plasma Ang Ⅱ in both V and NV groups were significantly higher than S group （ P 〈0. 001）, and there was no difference between V and NV groups （ P 〉0. 05）. OPlasma Ald was not different among all the groups （ P 〉0. 05）. Myocardial Ald was significantly
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2006年第10期596-599,共4页
Journal of Clinical Cardiology
关键词
高血压
肾血管性
左心室肥厚
醛固酮
缬沙坦
Hypertension,renovascular
Left ventricular hypertrophy
Aldosteron
Valsartan
