摘要
目的:探讨联合检测p21、p73及PTEN的表达状况在头颈部多原发癌诊断与鉴别诊断的意义。方法:应用免疫组织化学方法检测12例头颈部多原发癌组织中的p21p、73和PTEN蛋白表达,比较先证癌与第二癌间指标的表达状况。结果:12例头颈部多原发癌的先证癌与第二癌组织中p21、p73或PTEN单一指标表达结果不一致的分别为7例、3例、8例;联合对比p21和p73、p21和PTEN或p73和PTEN两指标表达结果存在不一致的分别为8例9、例、9例;联合对比p21、p73及PTEN三指标表达结果存在不一致的为10例。结论:应用免疫组化方法联合检测p21、p73及PTEN蛋白表达可提高头颈部多原发癌诊断的敏感性。多种相关基因蛋白表达的联合检测可成为头颈部多原发癌临床诊断与鉴别诊断的方法之一。
Objective： To investigate the value of detecting p21 ,p73 and PTEN in diagnosis of multiple primary cancers of head and neck. Methods： The expression of p21, p73 and PTEN was detected by SP immunohistochemical stains in 12 patients with multiple primary cancers of head and neck, and the expressive status of p21, p73 and PTEN was compared between the index and second cancer within each patient of these 12 consecutive ones. Results： Between the index and second cancer tissues, the expression of p21, p73 or PTEN protein was different in 7, 3 and 8 cases respectively. The comparison of integrated expression of p21 and p73, p21 and PTEN, p73 and PTEN was not consistent in 8, 9 and 9 cases respectively. The comparison of combined expression of p21, p73 and PTEN was discordant in 10 cases. Conclusion： It can increase the diagnostic sensitivity of multiple primary cancers of head and neck by detecting the combined expression of p21, p73 and PTEN.
出处
《山东大学耳鼻喉眼学报》
CAS
2006年第4期354-356,共3页
Journal of Otolaryngology and Ophthalmology of Shandong University
