摘要
采用微波辐射法,利用正交设计,以对-羟基苯甲醛和丙二酸为原料,甲苯、吡啶作为溶剂,苯胺作催化剂合成了对-香豆酸。最佳反应条件:在微波辐射下,反应物摩尔比为1:2(0.015mol:0.03mol),催化剂苯胺用量0.54g,辐射时间50min,产率达到72.76%。与传统法比较,微波辐射具有反应速度快、产率高的优点。
acid. The 0.015mol Microwave irradiation and orthogonal experiment optimum reaction conditions obtained were as were applied to synthesize P-coumaric follows： 0.54g aniline as the catalyst, P-hydroxybenzaldehyde and 0.030mol malonic acid （1：2）, 50min microwave irradiation. The yield rate reached 72.76%. Comparing with conventional ways, it shortened the reaction time and heightened the yield rate.
基金
兵团医药专项课题(No.NKB03BZSYY38XY)
关键词
对香豆酸
微波
正交
合成
P-coumaric acid
microwave
orthogonal experiment
synthesize
