摘要
目的探讨胃镜下不同程度表现的慢性胃炎患者血浆胃动素（MTL）水平的变化。方法慢性胃炎患者共106例，分为慢性浅表性胃炎（CSG）组和慢性萎缩性胃炎（CAG）组，其中CAG患者根据胃镜下表现细分为CAGⅠ、Ⅱ级两个亚组，另取胃镜所见无异常的18例作为对照。收集所有入选者空腹血浆标本用放免法测定其胃动素水平。结果CSG组MTL为（298.56±82．30）pg／mL，与对照组（274．22±65．78）pg／mL相比无显著性差异（P〉0．05），CAG组MTL（318．52±75．69）pg／mL水平高于对照组（P〈0．05）。CSG组与CAG组间MTL水平无显著性差异（P〈0．05），CAGⅠ级亚组（307．31±54．42）pg／mL与CSG无显著性差异（P〉0．05），CAGⅡ亚组（354．21±78．08）pg／mL高于CSG组和CAGI级亚组（P〈0．05）。结论CAG患者血浆MTL水平较健康人高，可能号慢性胃炎的发病机制有关。CAG程度越重，MTL水平改变越明显。
Objective To explore the relationship between serum motilin（MTL） levels and the endoscopic results in chronic gastritis patients, Methods One hundred and six patients with chronic gastritis were divided into two groups according to endoscopic results： chronic superficial gastritis （CSG） and chronic atrophic gastritis（CAG）, Subgroups of CAG were divided by endoscopic diagnosis grade Ⅰ and Ⅱ. There were eighteen patients selected as control group. Fasting blood MTL levels were measured by radioimmunoassay in 124 patients. Results There was no statistically significant difference in serum MTL level of CSG group （ 298.56± 82.30 ） pg/ml and control group （ 274.22± 65.78 ） pg/mL, the same as between CSG group and CAG group （ 318.52± 75.69 ） pg/ml. Serum MTL level in the CAG group （ 318.52±75.69 ） pg/ml was significantly higher than that in the Control group. There was no statistically significant difference in serum MTL level of CSG group and CAG grade I subgroup. Serum MTL level in the CAG grade II subgroup （ 354.21 ± 78.08 ） pg/ml was significantly higher than that in the CSG group and CAG grade I subgroup （ 307.31±54.42 ） pg/ml. Conclusion Serum MTL level is different in patients with CAG, which might be part of the pathogenesis of chronic gastritis. Serum MTL level is higher in more severe CAG patients.
出处
《微创医学》
2006年第1X期9-11,共3页
Journal of Minimally Invasive Medicine
关键词
慢性胃炎
胃镜分级
胃动素
Chronic gastritis
Endoscopic diagnosis grade
Motilin
