摘要
目的探讨缬沙坦阻断血管紧张素Ⅱ(AngⅡ)的作用后对心肌C反应蛋白(CRP)表达的影响。方法22只新西兰白兔随机分为3组:高脂饮食组(A组)、高脂饮食加缬沙坦组(B组)及对照组(C组)。喂饲10周后,取心肌用免疫组织化学方法测定CRP的表达。结果A组心肌CRP表达较C组明显升高(P<0.01)。与A组相比,B组心肌CRP表达显著降低(P<0.05),与C组比较差异无统计学意义。结论缬沙坦可降低心肌局部CRP的表达,减轻动脉粥样硬化的炎症反应对心肌的损害。
Objective To observe the effect of valsartan on decreasing the expression of C-reactive protein （CRP） in rabbits atherosclerotic myocardium. Methods Twenty-two male New Zealand white rabbits were randomly divided into three groups： cholesterol group （group A）, cholesterol ＋ valsartan-treated group （group B） and control group（group C）. The heart was harvested for immunohistochemistry measure of CRP after 10 weeks. Results Compared with control group, the expression of myocardial CRP in group A increased significantly （P〈0.01）. The level of myocardial CRP in group B was lower than that in group A （P〈0.05）. There was no difference between group B and group C. Conclusion Valsartan could reduce myocardial CRP.
出处
《中国药物与临床》
CAS
2006年第9期651-652,F0003,共3页
Chinese Remedies & Clinics
基金
山西省回国留学人员基金资助项目(200531)
关键词
C反应蛋白质
心肌
缬沙坦
动脉硬化
C-reactive protein
Myocardium
Valsartan
Arteriosclerosis
