摘要
CDX2是一种新发现的特异性的核转录因子,对正常和肿瘤性的肠上皮均有相对特异性和敏感性,用它作免疫组织化学染色可以用来诊断胃肠道起源的肿瘤以及辅助明确转移性肿瘤是否来源于肠道。目前与它相对应的常用的抗体是CDX2-88,它是一种单克隆抗体(小鼠IgGl、k抗体)。现就CDX2与结直肠肿瘤关系的研究及应用作一综述。
CDX2 is a recently found nuclear transcription factor, which is specific and sensitive to the normal and neoplastic intestinal epithelium. CDX2-88, a monoclonal antibody （ a mouse IgG1, kapa antibody）, is recently developed and usually used for CDX2. CDX2 immunohistochemistry has been shown to be useful in defining gastrointestinal origin in metastatic tumors and will likely become useful in addition to the standard panel of immunostains for carcinomas of unkown primary sites. This article reviews the previous studies of relationship of CDX2 and colorectal cancers.
出处
《国际遗传学杂志》
CAS
2006年第4期311-316,共6页
International Journal of Genetics
基金
国家自然科学基金(No.30570840)
关键词
CDX2
肠化生
免疫组化
腺癌
腺瘤
CDX2
Intestinal metaplasia
Immunohistochemistry
Adenocarcinoma
Adenoma
