摘要
[A Review] The process of apoptosis is very complex.Apoptosis-inducing factor(AIF)has the ability to induce apoptosis via a caspase-independent pathway.The mature AIF protein,a flavoprotein(prosthetic group:flavine adenine dinucleotide)is normally confined to the mitochondrial intermembrane space.AIF translocates through the outer mitochondrial membrane to the cytosol and to the nucleus.AIF induces nuclear chromatin condensation,as well as large scale(V50 kb)DNA fragmentation.AIF is a phyloge-netically old,bifunctional protein with an electron acceptor/donor(oxidoreductase)function and a second apoptogenic function and AIF acts in a caspase-independent fashion.The molecular mechanisms via which AIF induces apoptosis are discussed in this review.
The process of apoptosis is very complex. Apoptosis - inducing factor （AIF） has the ability to induce apoptosis via a caspase - independent pathway. The mature AIF protein, a flavoprotein （ prosthetic group ： flavine adenine dinucleotide） is normally confined to the mitochondrial intermembrane space. AIF translocates through the outer mitochondrial membrane to the cytosol and to the nucleus. AIF induces nuclear chromatin condensation, as well as large scale （ VSO kb ） DNA fragmentation. AIF is a phyloge - netically old, bifunctional protein with an electron acceptor/donor （ oxidoreductase ） function and a second apoptogenic function and AIF acts in a caspase -independent fashion. The molecular mechanisms via which AIF induces apoptosis are discussed in this review.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2006年第9期1858-1862,共5页
Chinese Journal of Pathophysiology
基金
首都医学发展科研基金资助(No. 2002 -2003)
关键词
细胞凋亡
凋亡诱导因子
Apoptosis
Apoptosis - inducing factor
