摘要
Many snake venoms contain complex mixtures of pharmacologically important molecules, some of which show potential therapeutic value in the treatment of cancer and other human disorders. In this review, we mainly reports the effects of snake venom active components, such as disintegrins and lectins in paralyzing cancer cells, blocking on cell migration, interaction with integrins, inhibition of tumor dissemination and angiogenesis. The advanced researches on the snake venom’s apoptosis-inducing components on tumors are also introduced. [
Many snake venoms contain complex mixtures of pharmacologically important molecules, some of which show potential therapeutic value in the treatment of cancer and other human disorders. In this review, we mainly reports the effects of snake venom active components, such as disintegrins and lectins in paralyzing cancer cells, blocking on cell migration, interaction with integrins, inhibition of tumor dissemination and angiogenesis. The advanced researches on the snake venom's apoptosis-inducing components on tumors are also introduced. [
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2004年第10期1938-1941,共4页
Chinese Journal of Pathophysiology
基金
国家自然科学基金资助项目 (No .39770 30 0 )
关键词
蛇毒液类
粘连
血管生成
病理性
细胞凋亡
肿瘤
Snake venoms
Adhesions
Angiogenesis, pathologic
Apoptosis
Neoplasms
