摘要
目的:研究凋亡抑制因子surv iv in和增殖因子M cm 5在食管癌发生发展过程中表达的意义及相互关系。方法:采用免疫组织化学(S-P)法检测22例食管正常黏膜、19例不典型增生、7例原位癌及139例浸润癌活检标本中sur-v iv in和M cm 5的表达情况。结果:①食管活检组织中,surv iv in和M cm 5蛋白在由正常向癌转变的过程中,表达逐渐增高,二者在正常黏膜中的表达均明显低于不典型增生、原位癌及浸润癌(P<0.05);②surv iv in蛋白表达与M cm 5蛋白表达之间呈正相关关系(P<0.05)。结论:食管癌的发生发展过程涉及凋亡抑制因子surv iv in的激活及增殖因子M cm 5功能的增强,二者联合应用有助于食管癌及其癌前病变的诊断。
Objective To study the significance of survivin protein and minichromosome maintenance 5 protein during the development of esophageal carcinoma and their correlation. Methods The expression of survivin and minichromosome maitenance 5 were detected with immunohistochemical technique in 187 biopsy specimens of esophagus. Of them, 22 were normal squamous epithelium, 19 were dysplasia, 7 were carcinoma in situ and 139 were invasive carcinoma. Results ① In esophageal biopsy specimens, survivin and minichromosome maintenance 5 expression were both gradually increased in a series of lesions from normal epithelium, dysplasia, to carcinoma. Survivin and minichromosome maintenance 5 expression in normal epithelium were significantly lower than those in dysplasia, carcinoma in situ and invasive carcinoma（P〈0. 05）; ②Survivin expression was positively correlated with minichromosome maintenance 5 （P 〈0. 05 ）. Conclusion The carcinogenesis and development of esophageal carcinoma involve the activation of survivin function and the enhancement of minichromosome maintenance 5 function. Survivin and minichromosome maintenance 5 may help the diagnosis of esophageal carcinoma and its precancerous lesions.
出处
《实用诊断与治疗杂志》
2006年第10期717-719,共3页
Journal of Practical Diagnosis and Therapy
基金
河南省科技攻关基金项目(项目编号0424410003)
教育部留学归国人员科研启动基金资助
关键词
食管癌
SURVIVIN
MCM5
癌前病变
活检组织
Esophageal carcinoma
survivin
minichromosome maitenance 5
precancerous lesions
biopsy tissues
