摘要
microRNA(miRNA)是近年来发现的一类长度约22个核苷酸非编码小分子RNA,它通过促使靶mRNA降解或抑制其翻译来调节靶基因的表达,在细胞的分化、增殖和凋亡,个体发育、机体代谢以及病毒感染中都具有重要的作用。随着研究的不断深入,目前认为miRNA在肿瘤发生发展过程中,具有与癌基因或抑癌基因相似的作用,有些致瘤病毒也编码miRNA影响宿主细胞,在肿瘤发生中可能具有重要的作用。利用这种作用,可将其作为抗肿瘤药物或者其他抗肿瘤药物的靶分子。
MicroRNAs （miRNAs） are non-coding small RNAs of about 22 nucleotides long, which have been found in recent years. By either direct cleavage or suppression of translation of their target mRNAs, miRNAs regulate the expression of their target genes. MicroRNAs are involved not only in the regulation of cell differentiation, proliferation and apoptosis, but also in the individual development, fat metabolism and viral infection. With the more progress achieved in study, it is now realized that miRNAs have the functions similar to oncongene or antioncogene, and that some virus-encoded miRNAs may play important roles in tumorigenesis. Therefore, MicroRNAs could be used as medication or the target molecules for cancer therapy.
出处
《医学分子生物学杂志》
CAS
CSCD
2006年第5期371-374,共4页
Journal of Medical Molecular Biology
