摘要
帕金森病(PD)是中老年人常见的中枢神经系统变性疾病。其主要病理改变是由基底神经节中的黑质多巴胺能神经元变性、缺失和黑质-纹状体通路变性引起的,临床表现为静止性震颤、肌僵直和运动迟缓等症状。基底神经节作为锥体外系统中的运动调节中心,与许多核团之间存在着纤维联系。研究证实中缝背核(DRN)与基底神经节及PD的关系密切,现就DRN与基底神经节及PD的关系简要综述。
Parkinson＇s disease（PD）, is one of the common elderly human neurodegenerative diseases, whose pathological changes always result from the degeneration and loss of dopaminerglc neurons in the substantia nigra of the midbrain, from the degeneration of substantia nigra-striatum pathway. PD＇s clinical symptoms are static tremor, splinting bradykinesia and so on. The basal ganglia, as the centre of regulating movements, has much fibrous connection with many nucleus masses. The study showed that nucleus raphes dorsalis has a close relationship with basal ganglia and PD, this article will review this view.
出处
《医学综述》
2006年第17期1061-1063,共3页
Medical Recapitulate
关键词
帕金森病
中缝背核
5-羟色胺
Parkinson＇s disease
Dorsal raphe nucleus
5-hydroxytryptamine
