摘要
用一次性被动回避性条件反射方法，观察了ｒ－氨基丁酸（ＧＡＢＡ＿Ｂ）受体（ＧＢ－Ｒ）激动剂巴氯芬（ｂａｃｌｏｆｅｎ）及ＧＫ－Ｒ受体拮抗剂ＣＧＰ＿（３５３４８）和ＣＧＰ＿（３６７４２）对小鼠学习和记忆获得、巩固及再现的影响；结果表明，ＧＲ－Ｒ拮抗剂可显著改善巴氯芬所致的学习和记忆获得障碍，并能显著改善巴氯芬、亚硝酸钠所致的记忆巩固障碍及巴氯芬、乙醇所致的记忆再现障碍，提示ＧＢ－Ｒ拮抗剂有望成为新型治疗老年性痴呆的药物。
In one trial passive avoidance response in mice,the effects of γ-aminobutyric acid(GABA)B receptor agonist baclofen and antagonist CGP35348 and CGP36742 on acquisition,consolidation and retrieval of memory were observed.The tesults showed that the antagonists couldsignificantly promote the acquisition impairment induced by baclofen, the consolidation impainnentinduced by baclofen and NaNO2,and the retrieval impairment induced by baclofen and 30 % alcohol.These results suggest that the GABA Breceptor antagonists may become a novel type of drug for thetreatment of Alzheimer'sdisease.
出处
《药学学报》
CAS
CSCD
北大核心
1996年第11期801-805,共5页
Acta Pharmaceutica Sinica
关键词
GABAB
受体拮抗剂
学习
记忆
氨基丁酸
γ-Aminobutyric acid_B receptor antagonist
Learning
Memory Present address:state Key Laboatory of Medical Neurobiology,Shanghai Medical University,Shanghai 200032,P.R.China.
