摘要
目的:探讨1型血管紧张素Ⅱ受体(AT1R)基因A1166C单核苷酸多态性在2型糖尿病合并高血压发病中的作用。方法:以222例江苏地区汉族人为对象,采用TaqManPCR及基因测序技术分析糖耐量正常(NGT)、2型糖尿病正常血压(T2DM-N)、2型糖尿病合并高血压(T2DM-H)人群AT1R基因A1166C单核苷酸多态性变异。结果:T2DM-H组AC基因型频率及C等位基因频率明显高于T2DM-N组(P=0.026,0.033);C等位基因参与T2DM合并高血压发病的相对危险度(以比数比表示)为3.194(95%CI1.049～9.724);Logistic回归分析表明AC型基因(OR=3.650,95%CI=1.120～11.894)及空腹胰岛素(OR=1.090,95%CI=1.000～1.188)为T2DM合并高血压的独立危险因素。结论:AT1R基因A1166C单核苷酸多态性与糖尿病合并高血压的发病相关,携带C等位基因的2型糖尿病患者罹患高血压的风险增加。
Objective：To explore the effects of A1166C polymorphism of angiotensin Ⅱ type 1 receptor（AT1R） gene on the development of type 2 diabetes mellitus（T2DM） complicated with hypertension, Methods：The variation of A1166C polymorphism of AT1R gene was detected in 222 people of Jiangsu district, including 121 cases of normal glucose tolerance （NGT）,60 cases of T2DM with normal blood pressure and 41 cases of T2DM complicated with hypertension, by means of TaqMan PCR and gene sequencing technology. Results ：The frequencies of AC genetype and C allele were significantly higher in patients with T2DM complicated with hypertension than those in patients with T2DM with normal blood pressure. The attributable risk of C allele for T2DM with hypertansion was 3.194 （95% CI 1.049-9.724）. Logistic regression analysis showed that genetype AC （OR = 3.650,95% CI = 1.120-11.894） and fasting insulin（OR = 1.090,95% CI = 1.000-1.188） were independent risk factors for T2DM combined with hypertension. Conclu- sion：These findings suggest that Al166C polymorphism of AT1R gene contributes to the development of hypertension in T2DM patients. The patients with T2DM presenting with AT1R gene C allele are more susceptible to hypertension.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2006年第9期764-768,共5页
Journal of Nanjing Medical University(Natural Sciences)
基金
国家自然科学基金资助项目(30100086)
江苏省自然科学基金资助项目(BK200159)
关键词
2型糖尿病
高血压
1型血管紧张素Ⅱ受体基因
单核苷酸多态
type 2 diabetes mellitus
hypertension
angiotensin Ⅱ type 1 receptor gene
single nucleotide polymorphism
