摘要
目的:探讨Ⅰ型血管紧张素Ⅱ受体(AT1R)基因A1166C多态性与2型糖尿病(DM)并发冠心病(CHD)、心肌梗塞(MI)的关系。方法:随机选择DM患者228例,其中并发CHD77例,MI30例,正常对照90例。多聚酶链扩增反应及DdeI限制性内切酶法检测A1166基因型。结果:组间基因型、等位基因频率比较:DM组与对照组无统计学差异(P>0.05);并发CHD组显著性高于无CHD组与对照组(P<0.05);并发CHD组中MI亚组显著高于非MI亚组(P<0.05)。结论:基因A1166C多态与DM无相关性,而参与DM并发CHD及MI。
Objective： To study the association between angiotensin Ⅱ type 1 receptor （AT1R） A1166C gene polymorphism and coronary heart disease （CHD） or myocardial infarction （MI） in type 2 diabetics. Methods： Two hundred and twenty-eight cases of type 2 diabetes mellitus, including 30 cases with CHD and MI, 47 cases with CHD and 90 controls were genotyped for A1166C gene polymorphism of AT1R by means of polymerase chain reaction（PCR） and Dde Ⅰ restriction enzyme digestion. Results： Frequencies of neither genotypes nor allele were significantly different between controls and DMS without CHD and MI, and between DMS without CHD and controls. Frequencies of genotypes and alleles were significantly higher in CHDS than those in no CHDS and controls. Frequencies of AC and CC genotypes and C allele were also significantly higher in those with MI than those without. Conclusion：T1RA1166C gene polymorphism has not association with type 2 diabetes mellitus, but contributes to the development of CHD or MI in type 2 diabetes mellitus.
出处
《山东大学学报（医学版）》
CAS
北大核心
2005年第11期1034-1036,1040,共4页
Journal of Shandong University:Health Sciences
