摘要
HBV复制周期包括两个重要的过程:一是自共价闭合环状DNA(cccDNA)产生转录模板,二是以前基因组RNA(pgRNA)为模板逆转录生成HBVDNA基因组。由于病毒以逆转录方式进行基因组的复制,所以时常产生病毒突变体。特定的选择压力,包括内源性的(宿主免疫清除)和外源性的(疫苗和抗病毒药物)易于选择出逃逸突变株。文章就HBV复制特点及其重要的基因变异进行综述。
Two of the key events in the viral life cycle of the hepatitis B virus involve generation from genomic DNA of the covalently closed circular DNA transcriptional template and reverse transcription of the viral pregenomic RNA to form the HBV DNA genome. Because the virus employs reverse transcription to copy its genome, mutant viral genomes are found frequently. Particular selection pressures, both endogenous （ host immune clearance） and exogenous （ vaccines and antivirals）, readily select out these escape mutants. This review delineates the characteristics of the hepatitis B virus replication and its important genetic variations.
出处
《国际流行病学传染病学杂志》
CAS
2006年第4期251-254,共4页
International Journal of Epidemiology and Infectious Disease
基金
国家重点基础973研究课题(2005CB523104)
关键词
乙型肝炎病毒
复制
突变
Hepatitis B virus
Replication
Variation
