摘要
我国HBV感染率高,由HBV感染导致的重型肝炎预后差。目前重型乙型肝炎发病机制尚未得到系统、完整的阐述,主要影响因素有病毒的生物学特性和宿主免疫功能状态及应答。在这两方面的研究中尚存在不少争议,关于它们所起的作用亦未得出统一的结论。笔者就HBV特性在重型肝炎发病中的可能作用,主要包括病毒微结构和复制特点、病毒的基因分型(包括型和亚型)和地区分布、病毒基因组中热点变异及准种变化对重型乙型肝炎发病的影响等进行综述。
There is a high prevalence of hepatitis B in China, and severe hepatitis due to HBV infection has poor prognosis. So far, the pathogenesis of severe hepatitis B has remained unclear, and the two major factors affecting the pathogenesis are the viral characteristics and the host immune status and responses. Nevertheless, there are controversies in the studies of the two aspects and a consensus on the role of the two factors has still not been reached. This review summarizes and analyzes the probable role of the viral characteristics in the pathogenesis of severe hepatitis B, mainly from the aspects such as HBV microstructure and the features of HBV replication, the classification and the area distribution of genotypes and subgenotypes, the hotspot mutations in the viral genome and the evolution of HBV quasispecies.
出处
《传染病信息》
2010年第2期76-79,共4页
Infectious Disease Information
基金
国家"十一五"科技重大专项(2008ZX10002-007)
