摘要
目的:探讨中药“虎杖丹参饮”治疗免疫性不育男性的临床疗效,为临床采用中医药治疗免疫性不育男性提供一种有效方法。方法:将符合纳入病例标准的90例患者随机分成两组,治疗组60例,采用口服“虎杖丹参饮”治疗;对照组30例,采用口服泼尼松治疗,分别治疗3个月,观察两组治疗前后临床症状改善、免疫指标[血清抗精子抗体(AsAb),精浆AsAb]、精液质量指标(液化时间、活力、活动率、密度、畸形率等)的变化,并对上述结果进行统计学分析。结果:①治疗组AsAb总转阴率明显优于对照组(P<0.01),其中血清AsAb转阴率疗效更好;②治疗组临床治愈率及总有效率明显优于对照组(P<0.01),治疗后的中医症状积分明显低于对照组(P<0.01),治疗组在改善临床症状方面明显优于对照组(P<0.01),尤以改善腰膝酸软、会阴睾丸坠胀、性欲强烈、局部疼痛症状明显;③治疗组治疗后精子活力、活动率明显优于治疗前(P<0.01),精子密度明显优于治疗前(P<0.05),而治疗前后的精液量、液化时间、精子畸形率及pH值没有明显差异(P>0.05)。结论:“虎杖丹参饮”治疗免疫性不育男性的疗效明显优于泼尼松。“虎杖丹参饮”能较好地提高AsAb转阴率,改善临床症状和精子质量,且无明显不良反应。“虎杖丹参饮”是治疗免疫性不育男性的有效方法。
Objective： To investigate the efficacy of the Chinese medicine Huzhangdanshenyin on male immune infertility, and provide an effective therapy for this disease. Methods ： Ninety men with immune infertility were selected as the research subjects and randomly divided into two groups, 60 in the treatment group, treated by Huzhangdanshenyin, and the other 30 in the control, treated by prednisone, both for 3 months. The improvement of clinical symptoms, immunologic indexes （ antisperm antibodies in serum and seminal plasma）and sperm indexes （semen liquefied duration, motility, viability, density and abnormal morphology rate） were observed and the results analyzed. Results ：①The total antisperm antibody reversing ratio of the treatment group was higher than that of the control （P 〈0.01 ）, especially the serum antisperm antibody reversing ratio.②There were significant differences in the clinical cure rate and total validity rate between the treatment group and the control （P 〈 0.01 ）. After the treatment, the markers of the clinical symptoms were lower（ P 〈 0.01 ）, and the improvement of the clinical symptoms was better in the treatment group than in the control（ P 〈 0.01 ）, especially the symptoms of pain in the back and knees, distending and bearing-down sensation of the perineum and testis, hypersexuality and topoalgia.③Compared with pre-treatment, sperm motility and viability of the treatment group significantly improved （ P 〈 0.01 ）, and so did sperm density （ P 〈 0.05）. However, there were no significant differences in sperm density, semen liquefied duration, abnormal morphology rate and pH （ P 〉 0.05） before and after the treatment. Conclusion ： The Chinese medicine Huzhangdanshenyin works more effectively than prednisone in the treatment of male immune infertility. It could improve the antisperm antibody reversing ratio, clinical symptoms and signs and ameliorate sperm indexes with no obvious advierse effects.
出处
《中华男科学杂志》
CAS
CSCD
2006年第8期750-755,共6页
National Journal of Andrology
基金
厦门市科技局资助(3502Z20037014)
关键词
免疫性不育
虎杖丹参饮
抗精子抗体
精液参数
男性
immune infertility
Huzhangdanshenyin
antisperm antibody
semen parameter
male
