摘要
目的:比较缬沙坦和苯那普利治疗原发性高血压患者的耐受性、安全性及左室肥厚逆转效应。方法:67例原发性高血压伴左室肥厚(LVH)患者随机分为缬沙坦和苯那普利组,分别服用缬沙坦80mg/d^160mg/d,苯那普利10mg/d^20mg/d。治疗6个月后,观察降压疗效比较治疗前后超声心动图指标。结果:应用缬沙坦和苯那普利后均有显著的降压和逆转效应。缬沙坦族具有良好的耐受性,未见干咳现象,苯那普利组干咳发生率8.5%。结论:缬沙坦治疗原发性高血压安全有效,逆转左室肥厚效应明显且耐受性好。
Objective To compare the tolerability, safety and efficacy of valsartan with benazapril in the treatment of essential hypertension and left ventricular hypertrophy（LVH）, Methods Sixty seven patients with LVH were randomly enrolled to receive either valsartan 80 mg/d-160 mg/d or benazapril 10 mg/d-20 mg/d for 6 months to observe the effects on lowering blood pressure and makers of heart Doppler ultrasound before and after treatment. Results Both valsartan and benazapril were effective atlowering blod pressure in benazapril group had dry cough but not observed in valsartan group. Conclusion Valsartan is effective and safe in patients with essential hypertension. It is effective and welltolerated to reverse left ventricular hypertrophy.
出处
《实用医技杂志》
2006年第13期2245-2246,共2页
Journal of Practical Medical Techniques
关键词
缬沙坦
苯那普利
高血压
左室肥厚
Valsatan Benazapril
Hypertension Left ventricular hypertrophy
