摘要
目的:制备槲皮素β-环糊精及羟丙基-β-环糊精包合物并对其加以鉴定。方法:分别以溶液搅拌法和有机溶剂挥发法制备槲皮素包合物;用相溶解度法判断槲皮素与β-CYD、HP-β-CYD形成包合物的摩尔比;并借助红外扫描法对包合物进行鉴定。结果:通过对两种制备方法的载药量进行比较,最后采用有机溶剂挥发法得到浅黄色疏松固体。经IR扫描发现:包合物已经形成;槲皮素与β-CYD、HP-β-CYD形成包合物的摩尔比1:1;槲皮素HP-β-CYD包合物能明显增加槲皮素在水中的溶解度。结论:包合后,槲皮素与环糊精形成新相,且溶解度有所提高。
Objective： To prepare the inclusion compound of quercetin - hydroxypropyl-β-cyclodextrin （ HP - β - CYD ） or quercetin-β-cyclodextrin （β-CYD） and identify them. Method： Those inclusion compounds were comfirmed by Solution Stirring method or Solvent Evaporation methods, respectively. Result： They were identified by IR absorption spectroscopy, those inclusion compounds were formed. The content analysis of the inclusion compound showed that the molecular ratio of quercetin to HP-β-CYD or β-CYD was 1 ： 1. The solubility of quercetin was increased from 0.028 mg·ml^ -1 to 2. 217 mg·ml^-1, when the drug is included by HP-β-CYD. Conclusion： A new physical phase forms between quercetin and HP-β-CYD or β-CYD, the solubility in water of quercetin can be increased.
出处
《中国药师》
CAS
2006年第8期701-702,共2页
China Pharmacist
关键词
槲皮素
包合物
增溶作用
Quercetin
Inclusion compound
Solubilization
