摘要
婴幼儿血管瘤的组织发生仍存在争议。近年来对与该病相关的血管形成生长因子、单克隆生长、免疫表型、内皮祖细胞、基因缺陷等多方面进行了较深入的研究。认为可能的发病机制是调控细胞增殖及分化的基因区发生突变的内皮祖细胞过度分泌血管形成因子,造成局部微环境血管形成/抑制的失衡,内皮细胞迅速增殖而形成婴幼儿血管瘤。
Although infantile hemangiomas （IH） are relatively common tumors, the underlying pathogenetic events and the biologic origin of this benign vascular neoplasm remains obscure. Recent advances in biomedical research, such as vascular growth factors, clonality of hemangioma endothelial cells, immunophenotype, endothelial progenitor cells （EPCs）, somatic mutations of IH, provide insights into a deeper understanding of the etiology of the tumor of childhood. These studies support the hypothesis that IH might arise from invading angioblasts or placental cells and these EPCs excessively secrete vascular growth factors, resulting in an increasing favorable local environment for endothelial proliferation, and contribute to aberrant endothelial growth in IH.
出处
《中国口腔颌面外科杂志》
CAS
2006年第4期311-314,共4页
China Journal of Oral and Maxillofacial Surgery
关键词
婴幼儿血管瘤
血管形成
克隆
基因突变
免疫表型
Infantile hemangiomas
Vascular development
Clonality
C, enetic mutations
Immunophenotype
