摘要
目的:比较溴化异丙托品(IPB)气雾剂与沙丁胺醇(SA)气雾剂分别使用及联合应用对哮喘和COPD患者的支扩作用。方法:对28例急性发作期的哮喘病人和36例急性加重期COPD患者于试验前后分别测定FEV1变化情况。结果:哮喘组:吸IPB、SA和SA+IPB前后,FEV1差值分别为0.17±0.10升,0.37±0.12升,0.61±0.14升,三组均比吸前FEV1显著增加(P<0.001),组间比较支扩作用:IPB+SA>SA(P<0.01),SA>IPB(P<0.01)。COPD组:吸IPB、SA及SA+IPB前后,FEV1差值分别为0.26±0.02升,0.25±0.03升,0.48±0.04升,三组均比吸药前FEV1显著增加(P<0.001),组间比较IPB+SA比IPB及SA组显著增加(P<0.01),IPB及SA组间未显示差异(P>0.05)。结论:SA和IPB对哮喘及COPD均有良好的支扩作用,IPB+SA联合应用比单独应用更有效,IPB对哮喘支扩作用不及SA,对COPD二者未显示差异。
Objective： To compare the effect of ipratropium bromide （IPB） with sulbutamol （SA）, on bronchodilatation in patients with asthma and COPD. Methods： Forced expiratory volumes in Ⅰ second （ FEV1 ） of 28 patpents with asthma and 36 patients with COPD were measured before and after inhaling IPB and or SA. Results： Improved （ P 〈 0.001 ） in patients with asthma and COPD · However, the improvement in FEV1 were significantly greater in SA ＋ IPB than IPB and SA （ P 〈 0.01 ） · FEV1 was significantly improved in SA than IPB （P 〈 0.01） in patient with asthma. FEV1 was no significantly improved, in SA and IPB in patients with COPD. Conclusion： Bronchodilatation in the patients with asthma and COPD is significantly improved after inhaling SA, IPB and IPB ＋ SA. But SA ＋ IPB was more effective than IPB and SA respectively in both asthma and COPD. SA was more effective than IPB in asthma, and there were no significant differences in COPD.
出处
《华西医学》
CAS
2006年第3期503-504,共2页
West China Medical Journal
