摘要
在细胞周期调控研究中，对ｃｙｃｌｉｎ－ＣＤＫ在细胞周期调控中作用机制的认识已获得突破性进展．近几年来，ＣＤＫ抑制因子（ＣＤＩｓ）家族成员──ｐ１６和ｐ２１的分离和研究，表明细胞周期蛋白（ｃｙｃｌｉｎ）与ＣＤＩ在调节ＣＤＫ活性方面形成了极为复杂的调控网络，从而控制细胞的增殖与分化，并与肿瘤的形成与发展相联系．
in the research of cell cycle regulation, the knowledge of the functions of cyclinCDKs in the cell cycle regulation has been madea signifcant progress. Recently, the isolationand studies of the family of CDK inhibitor proteins, p16 and p21, imply that cyclins and CDIsform a very complicated cascad regulation network in the regulation of the activity of CDKs,through which they impose control upon the proliferation and differentiation of cell, are relatedto the formation and development of cancer.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
1996年第5期417-421,共5页
Progress In Biochemistry and Biophysics
