摘要
目的了解糖尿病伴尿路感染的病原菌分布及耐药性，指导临床合理用药。方法选择近两年的住院糖尿病伴尿路感染患者299例次，对培养出致病微生物120株进行分析。耐药株的检测及体外药敏试验均采用K-B法。结果糖尿病组前三位细菌为大肠埃希氏菌（55．0％），粪肠球菌（9．2％），光滑球拟酵母菌（7．5％）；耐药后五位的是氯霉素、阿米卡星、头孢他啶、呋喃妥因、亚胺培南，均在28．8％以下。对G^＋球菌耐药抗生素，后四位的是氯霉素、呋喃妥因、亚胺培南、万古霉素，均在17．4％以下。抗真菌药物伊曲康唑及氟康唑耐药率在10．5％～26．3％之间。结论尿培养及药敏结果对临床治疗有较高的指导价值，应尽量选用药敏试验敏感的药物治疗，根据具体情况及复查结果决定药物种类和治疗时间以及是否联合应用抗生素。
Objective To study the distribution and drug-resistance of the pathogen in diabetic with urinary tract infection, and direct rational use of antibiotic in clinical. Method 229 in-patients were chosen in recent two years,which were accompanied with diabetes and urinary tract infection. 120 cases were cultivated with pathogen. K-B method was used to test the drug-resistant strain and do drug-sensitivity test. Result The former three bacteria in diabetic with urinary tract infection were escherichia coli （55.0%）, dung enterococcus （ 9.2% ）, and microzyme （ 7.5 % ）. The last five resistant antibiotics were chloromycetin, amikacin,ceftazidime, nitrofurantoin, and Imipenem, were all below 28.8%. The last four antibiotics which were not sensitive to G^＋ cocci, were chloromycetin, nitrofurantoin, Imipenem, and vancomycin,were all below 17.4%. The drug-resistance rate of pathogen to antifungal, such as fluconazole and itraconazole,was 10.5% - 26.3%. Conclusion The result of urine cultivation and drug sensitivity are useful to clinic. It is important to choose antibiotic under the direction of it.
出处
《临床内科杂志》
CAS
2006年第7期473-475,共3页
Journal of Clinical Internal Medicine
关键词
糖尿病
耐药性
药敏试验
病原菌
大肠埃希菌
Diabetes mellitus
Drug resistance
Drug sensitivity test
Pathogen
Escherichia coli
