摘要
人工麝香为代替中药麝香的原料药，属中药Ⅰ类新药。本研究对其致突变性进行评价。当人工麝香的剂量为１８００、７００和３５０ｍｇ／ｋｇ时，昆明种小鼠骨髓嗜多染细胞的微核率分别为２．８‰、１．３‰和１．０‰；当人工麝香浓度为６２５、１２５０、２５００和５０００μｇ／皿时，无论加或不加Ｓ９混合物对ＴＡ９７、ＴＡ９８、ＴＡ１００和ＴＡ１０２菌株的回复突变作用均为阴性。当人工麝香剂量为３６０、１８０和９０ｍｇ／ｋｇ时，小鼠骨髓染色体畸变率分别为１．０％、０．８％和１．２％。上述结果表明，人工麝香没有致突变作用。
Artificial musk-raw Material,using as a substitute for traditional Chinese medicinemusk,a new drug of class Ⅰ was assessed for mutagenicity.The micronucleus rates of polychromatocyte in the bnoe marrow of mice were 2.8,1.3 and 1.0‰ when the treated dosagewas 1800,700 and 350 mg/kg.The results of Ames test for the strains TA97,TA98,TA100 and TA102 were negative with and without S9 mix when the concentration of artificial musk was 625,1250,2 500 and 5 000 μg/plate,respectively.The chromosome aberration rates were 1.0,0.8,1.2%when the treated dosage was 360,180,90 mg/kg,respectively.The above results proved that no mutagenicity was found for artificial musk.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1996年第6期435-438,共4页
Acta Academiae Medicinae Sinicae
关键词
人工麝香
致突变性
AMES试验
微核
染色体畸变
artificial musk
mutagenicity, Ames test
micronucleus test
chromosome aberration
