摘要
目的:观察氯米帕明合用奎硫平治疗强迫症的临床疗效及不良反应。方法:将强迫症患者65例随机分为三组,分别用氯米帕明合并奎硫平、氯米帕明合并氯丙嗪及单用氯米帕明治疗8周。用强迫症量表(Y-BOCS)评定疗效,用副反应量表(TESS)评价不良反应。结果:合用奎硫平组和合用氯丙嗪组均显著提高显效率(P<0.05),4周后Y-BOCS评分较治疗前均明显下降(P<0.05),合用奎硫平组氯米帕明剂量较单用组低(P<0.05),且不良反应低(P<0.05)。结论:奎硫平是较好的强迫症增效剂,疗效较好,不良反应轻。
Objective：To study the efficacy and side - effect of chlorimipramine with Quetiapine for the treatment of patients with obsessive - compulsive disorder. Methods： Patients with obsessive - compulsive disorder were randomly assigned to take chlorimi- pramine combined with Quetiapine, chlorimipramine combined with chlorpromazine, or chlorimipramine singly for 8 weeks. Efficacy was assessed in Yale - Brown obsessive - compulsive psychiatrists rating - scale. Side - effect was assessed in Tess. Results： Chlorimipramine combined with Quetiapine Treat - patients and chlorimipramine combined with chlorpromazine Treat - patients demonstrated significantly improvement （P〈 0.05）, Score on Y - BOCS demonstrated significantly decrease 4 weeks later compare to pie - treatment （ P〈 0.05 ）, Doses of chlorimipramine in chlorimipramine combined with Quetiapine group is lower compare to single group （ P〈0.05 ）, and side - effect is lower （ P 〈0.05 ）. Conclusions： Quetiapine is a synergist of obsessive - compulsive disorder, it is effective and side -effect is lower.
出处
《中国民康医学》
2006年第13期576-577,共2页
Medical Journal of Chinese People’s Health
关键词
氯米帕明
奎硫平
氯丙嗪
强迫症
Chlorimipramine
Quetiapine
Chlorpromazine
Obsessive - compulsive disorder
