摘要
目的:比较利培酮合并氯丙咪嗪对强迫症的临床疗效及不良反应。方法:按前瞻性、随机单盲法,将67例强迫症患者随机分为利培酮合并氯丙咪嗪组和氯丙咪嗪组,疗程10周。在疗前,疗后2、4、6、8、10周用Yale-B rown强迫量表(Y-BOCS),汉密尔顿焦虑量表(HAMA),汉密尔顿抑郁量表(HAMD),副反应量表(TESS)和临床疗效评定标准,评定疗效及不良反应。结果:利培酮合并氯丙咪嗪组起效快,第2周末时各分值与治疗前比较差异有显著性(P<0.05)。两组从第4周末始各分值与治疗前比较差异均有极显著性(P<0.01)。第4、6、8、10周两组间各分值比较差异均有显著性(P<0.05)。利培酮合并氯丙咪嗪组总体疗效优于氯丙咪嗪组,两组有效率差异有显著性(P<0.05),两组不良反应发生率均较低,差异无显著性(P<0.05)。结论:利培酮合并氯丙咪嗪治疗强迫症较氯丙咪嗪好,起效快,依从性好,不良反应轻,值得推广。
Objective：To compare the efficacy and side effects of Risperidone and Clomipramine in the treatment of obsessive -compulsive disorders （OCD）. Methods-Sixty -seven patients were randomized to Risperidone and Clomipramine group and Clomipramine group according to foresight and single - blind for 10 weeks. The efficacy was measured with Y - BOCS, HAMA and HAMD and the side effects were determined by TESS before and after the second, fourth, sixth, eighth and the tenth week. Results, Risperidone and Clomipramine group took effect quickly. At the end of the second week, there was marked difference than before （P 〈 0. 05）. But the two groups both took effect obviously at the end of the fourth week （ P 〈 0.01 ）. And there was marked difference in the fourth , sixth, eighth and tenth week between the two groups （P 〈 0.05 ）. Risperidone and Clomipramine group is more efficient than the Clomipramine group. There was the more obvious difference between effective rate of two groups （ P 〈 0.05 ）. The side effects of two groups are both low. There was no marked difference （P 〈 0.05 ）. Conclusions： It is better to use both Risperidone and Clomipramine than only to use Clomipramine. The combination of Risperidone and Clomipramine is an effective method with few side effects and takes into effect rapidly in the treatment of OCD and has better response in obsessive thoughts.
出处
《中国民康医学》
2007年第5期178-180,共3页
Medical Journal of Chinese People’s Health
关键词
神经症
强迫症
利培酮
氯丙咪嗪
治疗
Neurosis
Obsessive - compulsive disorder
Risperidone
Clomipramine
