摘要
The human leucocyte antigen （HLA） complex on chromosome 6p21.3 is the most extensively studied genetic region in Inflammatory bowel disease （IBD）. Consistent evidence of linkage to IBD3 （6p21.1-23）, an area which encompasses the HLA complex, has been demonstrated for both Crohn＇s disease and ulcerative colitis, and a number of replicated associations with disease susceptibility and phenotype have recently emerged. However, despite these efforts the HLA susceptibility gene （s） for IBD remain elusive, a consequence of strong linkage disequilibrium, extensive polymorphism and high gene density across this region. This article reviews current knowledge of the role of HLA complex genes in IBD susceptibility and phenotype, and discusses the factors currently limiting the translation of this knowledge to clinical practice.
染色体 6p21.3 上的人的白细胞抗原(HLA ) 建筑群是在煽动性的肠疾病(IBD ) 的最广泛地学习的基因区域。到 IBD3 (6p21.1-23 ) 的连接的一致证据，包含 HLA 建筑群的一个区域，为两 Crohn 的疾病被表明了， ulcerative，和有疾病危险性和显型的很多个复制协会最近出现了。然而，尽管有这些努力为 IBD 遗体的 HLA 危险性基因(s) 逃犯，越过这个区域的强壮的连接不平衡，广泛的多型性和高基因密度的后果。这篇文章在 IBD 危险性和显型考察 HLA 复杂基因的角色的当前的知识，并且讨论当前限制这知识的翻译到临床的实践的因素。
