摘要
目的测定4个不同厂家(分别以A,B,C,D,表示)芒果止咳片的体外溶出度,为评价和控制药品质量提供参数与依据。方法按《中国药典》2000年版进行,以蒸馏水为释放介质,用紫外分光光度法在259 nm波长处测定紫外吸收度;使用SPSS一般线性模型(General L inerModel)对不同厂家芒果止咳片的体外溶出度进行多重比较。结果厂家A,C,D分别与厂家B的溶出度有显著差异(P<0.005),而厂家A,C与D之间无显著差异(P>0.05)。结论有必要测定芒果止咳片的体外溶出度。
Objective The dissolution rates of baical in in Mangguozhike Tablets were determined to provide a basis for evaluating and controlling the drug quality. Methods The dissolution rates of Mangguozhike tablets with different batch numbers were determined by UV,using water as dissolution medium. Results The T50 of Mangguozhike tabletes was 45.57 -62.96 rain and there were significant differences in dissolution parameters between tablets tested（P 〈 0. 005）. Conclusion It is suggested that the dissolubility of each batch of products should be tested to control the quality and ensure clinical efficacy.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2006年第6期967-968,共2页
Lishizhen Medicine and Materia Medica Research
