摘要
目的:探讨气道内悬挂125I粒子2种不同剂量治疗中心型肺癌引起的气道狭窄的疗效和不良反应。方法:采用环甲膜穿刺、置管、气道内分别悬挂单列(A组)、双列(B组)125I放射性微粒子,对中心型肺癌气道狭窄进行持续近距离放疗,治疗3个月。结果:22例患者中,A组气道狭窄缓解率为63%,B组气道狭窄缓解率为81%,2组缓解率无明显差异(P>0.05);呼吸道症状和胸痛的缓解率也无明显差异(P>0.05),PEF%有明显差异(P<0.05)。结论:气道内悬挂125I粒子治疗癌性气道狭窄有较好疗效,种子源单列或双列排列对气道狭窄缓解率无明显差异,悬挂双列种子源对改善肺功能更有帮助。
Objective：To evaluate the effectiveness and safety of two different irradiation dosages of endobronchial 125^Ⅰ seeds for malignant airway stenosis induced by central lung cancer. Methods： Endobronchial brachytherapy was performed by implanting and suspending one （Group A） or two rows （Group B） of 125^Ⅰ seeds in airway via cricothyroid membrane puncture. Radiotherapy lasted three months. Results：Of 22 cases, airway stenosis was ameliorated in 63 % patients in group A and 81% patients in group B （complete response rate＋ part response rate）. There was no significant difference between the two groups（P〈 0.05）. The respiratory symptoms and chest pain were relieved in both groups with no significant difference（P〉0.05）. But the percentage of peak expiratory flow （PEF%） was significantly different between the two groups（P〈0.05）. Conelusion： Suspension of 125^Ⅰ seeds in airway is effective in management of malignant airway stenosis. No significant difference was found between the two irradiation dosages of 125^Ⅰseeds. Implantation of two rows of 125^Ⅰ seeds was more helpful to improve lung function.
出处
《肿瘤》
CAS
CSCD
北大核心
2006年第6期570-572,585,共4页
Tumor
基金
河北省卫生厅2004年资助项目(编号:04034)
