摘要
目的:运用Meta分析的方法综合评价中国人群β-Fg-455G/A基因多态与缺血性脑卒中发病关系。方法:检索中国生物医学文献数据库(CBMdisk)、中国学术期刊全文数据库(CNKI)、Medline1994-01/2005-12相关文献,纳入内容涉及β-Fg-455G/A基因多态的基因型频率和(或)等位基因频率的独立病例对照研究,去除重复报告、数据描述不清无法利用的文献。按上述要求初步筛查文献为12篇,Hardy-Weinberg遗传平衡检验后纳入Meta分析文献为10篇,累积病例组1270例,对照组1302例。以病例组和对照组基因分布OR值为效应指标,应用RevMan4.2软件对各研究结果进行一致性检验和数据合并。结果:数据合并结果显示,病例组GA+AA基因型频率和等位基因A频率明显高于对照组,总体效应检验:P=0.01,OR=1.44,95%CI=(1.09～1.91);P<0.001,OR=1.47,95%CI=(1.19～1.82)。结论:中国人群β-Fg-455G/A基因多态的GA+AA型与缺血性脑卒中呈正相关,即455G→A突变与缺血性脑卒中有关。
AIM： To investigate the relationship between β-fibrinogen gene-455G/A polymorphism and the risks for ischemie stroke in Chinese by Meta-analysis.
METHODS： Computer-based online search of CBMdisk, CNKI and Meal- line were undertaken for related articles published between January 1994 and December 2005. The ease-control reports about the frequencies of genotypes and/or alleles of β-fibrinogen gene-455G/A were inclusive, and the repetitive reports or studies with inaccurate statistics were excluded. Totally 12 literatures were collected firstly, and 10 papers were selected for Meta analysis after Hardy-Weinberg equilibrium test including 1 270 patients as the cumulative ease group and 1 302 as the control group. With the odds ratio （OR） of the case and control groups as the effective index, RevMan 4.2 software was applied for the Consistency checking among individual studies and data combining.
RESULTS： The combined data statistics revealed that the frequencies of G/A ＋ A/A genotype and A allele in the ease group were significantly higher than that in the control group [test for overall effect： P=0.01, OR =1.44, 95%CI=（1.09, 1.91）; P 〈 0.001, OR=1.47, 95%CI=（1.19, 1.82）].
CONCLUSION： In Chinese population, the GA＋AA genotype of β-fibrinogen gene-455G/A polymorphism is positively correlated with isehemie stroke, which means 455G→A mutation is related to ischemie stroke.
出处
《中国临床康复》
CSCD
北大核心
2006年第24期30-32,共3页
Chinese Journal of Clinical Rehabilitation
