摘要
目的探讨双相抑郁和复发性抑郁住院患者的临床特征及相关因素。方法回顾性分析1999年到2001年我院诊断情感障碍住院病人506例,比较双相抑郁107例和复发性抑郁399例人口学资料、病程、诊断及疗效等变量。结果复发性抑郁组女性比例高于双相抑郁组(268/399比54/107,χ2=10.17,P<0.01);复发性抑郁组以往多次抑郁发作史低于双相抑郁组(41.4%/57%,χ2=8.4,P<0.01),病程短于双相抑郁组(58.8±4.5/96.3±9.6,t=-3.77,P<0.01),首次抑郁年龄大于双相抑郁组(41.7±0.8/29.4±1.4,t=6.95,P<0.01),首次抗抑郁治疗有效率大于双相抑郁组(81.3%/57%,χ2=95.2,P<0.01),复发抑郁组同一次病程首次诊断符合率高于双相抑郁组(97%/31.8%,χ2=324.4,P<0.01),双相抑郁组中61.7%(66/107)首次诊断为抑郁起病年龄20岁左右者发生双相抑郁概率明显大于60岁以后起病者(OR=2.45)。病程5年以上发生双相抑郁概率大于病程短于1年者(OR=2.75),首次抗抑郁疗效差出现双相抑郁概率大于首次抗抑郁疗效好者(OR=3.18)。双相抑郁组同一次病程61.7%首次诊断抑郁障碍。结论首发抑郁的年龄、病程、首次抗抑郁效果与出现双相抑郁的概率有关。首发抑郁年龄越早,病程越长,首次抗抑郁疗效越差,发生双相抑郁概率越大。2/3双相抑郁首次诊断复发性抑郁。
Objective： To compare clinical features of bipolar and unipolar inpatients. Methods： Retrospective analysis was used with records of inpatients of our hospital. 107 inpatients with diagnosis of bipolar depression and 399 with current depression were enrolled, whom had been hospitalized in our hospital between 1999 and 2001. Demographic data, course of disease, diagnosis shifts and therapeutic effects were analyzed. Results： The rate of female was lower in bipolar group than in recurrent depression group （ 54/107 vs. 268/339, X^2=10. 17, P 〈 0. 01 } . More bipolar patients had recurrent depressive episodes before （ 57% vs. 41.4%, X^2=8.4, P 〈 0. 01 ） . Bipolar patients was younger when they first had depressive episode （ 29.4±1.4/41.7±0. 8, t=6. 95, P 〈 0. 01 ）, they also had longer course of disease （ 96. 3±9.6/58.8±4. 5 months, t=3.77, P 〈0.01） . Bipolar patients had lower response rate to antidepressants when they first had depression （ 57% vs. 81.3%, X^2=95. 2, P〈0. 01 ） . Nearly two third （ 66/107, 61.7% ） bipolar patients first diagnosed as major depression. The risk factor for bipolar depression included first episode at young （ about 20 years vs. over than 60, OR=2. 45）, poor response to antidepressants at onset （ or = 3. 18）, longer course of disease （more than 5 years vs. less than 1 year, OR =2. 75） . Conclusions： Early onset, with course longer than 5 years and poor response to antidepressant are main factors predict bipolar depression. 2/3 bipolar depressions were first diagnosed as recurrent depression.
出处
《中国心理卫生杂志》
CSSCI
CSCD
北大核心
2006年第6期404-406,共3页
Chinese Mental Health Journal
