摘要
目的了解大肠腺瘤癌变的危险因素,为临床诊治提供参考.方法对1992～2002年我院接受纤维结肠镜检的大肠腺瘤患者630例,有明确病理诊断的腺瘤共849枚进行回顾性分析.结果 （1）大肠腺瘤好发于直肠和乙状结肠, 直肠腺瘤的癌变率最高,比较差异有统计学意义（P〈0.05）;（2）大肠腺瘤患者好发年龄为50～79岁,随着年龄的增加腺瘤癌变率有增加的趋势,比较差异有统计学意义（P〈0.05）;（3）大肠腺瘤的组织类型中管状腺瘤最多,癌变率从高到低的顺序依次为绒毛状腺瘤、混合性腺瘤、管状腺瘤,比较差异有统计学意义（P〈0.05）;（4）大肠腺瘤随着直径的增大变得易癌变,比较差异有统计学意义（P〈0.05）;（5）大肠腺瘤具有多发性,多发性腺瘤患者较单发性腺瘤患者易发生腺瘤癌变,比较差异有统计学意义（P〈0.05）;（6）大肠腺瘤癌变的主要危险因素依次为腺瘤大小,组织类型,患者年龄.结论 （1）〉70岁患者,多发性腺瘤患者易发生腺瘤癌变;（2）绒毛状腺瘤,直肠腺瘤,直径〉2cm腺瘤易癌变;（3）大肠腺瘤癌变的主要危险因素依次为腺瘤大小、组织类型、患者年龄.
Objectives To find the dangerous factors leading to the canceration of the adenomas of large intestine to supply reference for clinic. Methods Six hundreds and thirty patients with 849 adenomas of large intestine who received colonoscopy from 1992 to 2001 were analyzed retrospectively. Results （1） The distribution of adenomas was mainly in rectum and sigmoid and the adenomas in rectum had the highest canceration rate （P〈0.05）. （2） The age of the patients with adenomas of large intestine was mainly from 50 to 79 years and there was a higher canceration rate with the patients age increasing （P〈0.05）. （3） In all kinds of the histology type, the tubular adenoma accounted for the most. The canceration rate of the adenoma of large intestine from high to low in sequence was villous adenoma and tubular-villous adenoma, tubular adenoma（P〈0. 05）. （4） The big adenoma of large intestine was easier to cancerate than the small one （P〈0.05）. （5） There was a multiple nature for the adenomas of large intestine. The patients with multiple adenoma accounted for 27.78% and there was a higher canceration rate for the patients with multiple adenoma than for the patients with single adenoma （P〈0.05）. （6） The main dangerous factors for adenoma canceration in sequence were the size of adenoma, the histology type of adenoma and the patient＇s age. Conclusion （ 1 ） The canceration of the adenomas of the large intestine easily occurs in patients older than 70 and patients with multiple adenomas. （2） The villous adenomas, the adenomas with diameter larger than 2cm and the rectum adenomas easily cancerate. （3） The main dangerous factors for adenoma canceration in sequence are the size of adenoma, the histology type of adenoma and the age of the patient.
出处
《重庆医学》
CAS
CSCD
2006年第11期1019-1021,共3页
Chongqing medicine
关键词
大肠腺瘤
癌变
结肠镜检术
adenoma of the large intestine
canceration
colonoscopy
