摘要
目的：探讨纳洛酮与氨茶碱联合应用治疗早产儿原发性呼吸暂停的疗效。方法：所有患儿均在首次发生呼吸暂停后予以氨茶碱治疗，用至呼吸暂停终止发作后48h，治疗组在应用氨茶碱的基础上加用纳洛酮，首次按0．1mg／kg静脉注射，随后改为0．01mg,／（kg·h^-1）静脉泵入，持续6～8h，共5d，对照组不加用纳洛酮。结果：与对照组比较，治疗组日平均发生呼吸暂停次数减少（P〈0．01），呼吸暂停终止时间、氨茶碱使用时间缩短（P〈0.01），发生呼吸暂停时心率、Sp02下降程度减轻（P〈0．01）；治疗组总有效率92．8％，而对照组总有效率为70％，治疗组优于对照组（P〈0．05）。结论：纳洛酮与氨茶碱联合使用比单用氨茶碱效果好，在临床上值得应用。
Objective： To observe the clinical benefits of naloxone plus aminophylline in treatment of primary apnea of premature infants. Methods： all the infants were treated with aminophylline after first onset of apnea until the condition was absent for 48 hours. In the treatment group, intravenous injection of naloxone was added on aminophylline with an initial dose of 0. 1mg/ kg, followed by 0.01 mg/（ kg · h ^-1 ） intravenous pumping lasting 6-8 hours daily for 5 consecutive days. No naloxone was added in the control group. Results ： compared with the controls, the treatment group experienced less episodes of apnea [ （3.0 ± 1. 1 ）/d vs （4.4 ± 1.4）/d in the controls] （P 〈 0. 01 ）, shortened duration of apnea [ 4.5 ± 0.8 ） days vs （ 5.8 ± 1.2 ） days ] and less aminophylline days [ （ 6.4 ± 1,1） daysvs （8.1 ±1.6） days] （both P〈 0.01）. Reduction inSpo2[（79.2±4.0）% vs （74.9±6.7）%], and heart rate [ （ 85.9 ± 6.1 ） beats/min vs （ 79.2 ± 5.8 ） beats/min ] were alleviated with naloxone plus aminophylline （beth P 〈0. 01 ）. The total effective rates of the treatment group were 92.8% , much lower than that in control group （70%） （ P 〈 0.05 ）. Conclusions. Naloxone plus aminophylline in treatment of primary＂ apnea of premature infants showed better benefit compared with aminophylline alone, and is worthy of recommendation for use in primary apnea of premature infants.
出处
《广州医学院学报》
2006年第1期47-49,共3页
Academic Journal of Guangzhou Medical College
