摘要
目的观察氨茶碱联合纳洛酮治疗早产儿原发性呼吸暂停的疗效。方法将62例原发性呼吸暂停早产儿随机分为治疗组和对照组,各31例。两组患儿在首次发生呼吸暂停后均给予氨茶碱负荷量5mg/kg,于20min内静脉滴注,12h后给予2.5mg/kg维持量,12h静脉滴注1次。治疗组同时加纳洛酮,首次予0.1mg/kg静脉注射,继而按0.1mg/kg加10%葡萄糖液20mL以0.02～0.04mg.kg-1.h-1静脉泵入。结果治疗组总有效率为93.5%,对照组为67.7%,两组比较,差异有统计学意义(P<0.05)。结论氨茶碱联合纳洛酮治疗早产儿原发性呼吸暂停比单用氨茶碱更有效。
Objective To observe the clinical benefits of aminophylline plus naloxone in treatment of primary apnea of premature infants. Methods 62 cases were divided into treatment group and contrast group. 31 cases were in the treatment group,S1 cases were in the contrast group. When the infant appeared apnea symptom, aminophylline 5 mg/kg, the loading dose. were given at 20 rain with vein infusion,after 12 h,aminophylline usage was 2.5 mg/kg,the maintenance dose,every 12 h intravenous drip once. Plus naloxone in treatment group,naloxone usage was 0. 1 mg/kg firstly, intravenous injection, and then 0. 1 mg/kg with intravenous pump to be followed by a 10% and 20 mL glucose injection,speed is 0.02--0.04 mg ·kg ·h^-1. Results The total effective rate of in the treatment group were 93.5% ,much higher than that in contrast group 67.7%. The difference between the two groups was statistically significant （P〈0.05）. Conclusion Aminophylline plus naloxone in treatment of primary apnea of premature infants showed better benefit compared with aminophylline alone.
出处
《重庆医学》
CAS
CSCD
北大核心
2010年第15期2027-2028,共2页
Chongqing medicine
