摘要
目的通过观察运动病大鼠降钙素基因相关肽(CGRP)在前庭传出性中枢神经系统和前庭核的表达变化,探讨中枢CGRP在运动病发病过程中的作用。方法30只SD大鼠随机分为3组,其中不给予旋转运动刺激的为对照组,其它两组实验动物通过电动转椅分别给予3次和1次运动性刺激,刺激后即刻取各组动物脑干切片,用ABC法观察传出性前庭神经系统和前庭核的CGRP免疫组化反应变化。结果运动病大鼠前庭传出性神经系统和前庭核CGRP反应与对照组相比明显增强,且刺激3次组强于刺激1次组。结论CGRP在大鼠运动病的发病过程中发挥了一定的作用。
Objective To study the changes of calcitonin gene related peptide（CGRP） in the etterent vestibular system and vestibular nuclei in rats with motion sickness. Method Thirty rats were divided into 2 experimental groups and 1 control group,and rats in the 2 experimental groups were treated with rotatory stimuli for 30 rain 1 time and 3 times respectively. CGRP in rat efferent vestibular sys- tem and vestibular nuclei were observed utilizing ABC immnunohistochemical technique. Result Number of CGRP immunoreactivity neurons in the efferent vestibular system and level of CGRP immunoreactivity in vestibular nuclei increased significantly in rats after rotatory stimuli, and the changes were greater in the goup with 3 times of stimuli than those in the group with 1 time of stimulus. Conclusion CGRP might play a role in the process of motion sickness in rat.
出处
《航天医学与医学工程》
CAS
CSCD
北大核心
2006年第3期167-170,共4页
Space Medicine & Medical Engineering
关键词
降钙素基因相关肽
运动病
前庭传出系统
前庭核
基因表达
calcitonin gene related peptide
motion sickness
efferent vestibular system
vestibular nuclei
gene expression
