摘要
目的了解玉溪市革兰阴性杆菌的耐药分布与变迁，为临床用药提供依据。方法对玉溪市人民医院1999—2004年临床各科送检的各类标本中培养分离出的4544株革兰阴性杆菌作回顾性分析。结果9种（属）细菌对25种药物的药敏结果耐药率〉50％者72种次（40．9％），〈20％者44种次（25．0％）。总的耐药情况为不动杆菌和阴沟肠杆菌最高，铜绿假单胞菌和大肠埃希菌次之，甲型副伤寒沙门菌和福氏志贺菌最低。亚胺培南对多种细菌有较高的敏感覆盖率。有4种细菌对10种抗菌药物耐药率的上升具有临床意义（P〈0.01或P〈0．05），其中以甲型副伤寒沙门菌对氟喹诺酮类上升最为显著。结论临床分离革兰阴性杆菌的耐药形势十分严峻，应定期监测区域内细菌的耐药变化．指导临床合坪用药。
Objective To study the distribution and variation of antibiotic-resistant rate of Gram-negaive bacilli for the guidance of rational use of antibiotics in Yuxi city. Motbod A retrospective analysis 4 544 strains of Gram-negative bacilli isolated from clinical specimen in 6 years （ 1999 -2004） in Yuxi city people＇s hospital was carded out. Results The 9 species （groups） bacteria to 25 kinds of antibiotics by the antibiotic susceptibility tests showed that the antibiotic-resistant rate 〉 50% had 72 species（40.9% ） and 〈 20% had 44 species （25.0%） . The total of antibiotic resistance were as follows Acinetobaeter and Enterobacter cloacae were the highest, the next were Pseudomonas aeruginosa and Escherichia coli, Salmonelld paratyphi A and Shigellaflexneri were the lowest. These bacteria to imipenem showed excellent activity. The uprise of antibiotic-resistant rate had clinical value （ P 〈 0.01 or P 〈 0.05 ） on 4 species bacteria to 10 kinds antibiotics. The rise of Salmonella paratyphi A to guinolones was great notable. Conclusions The situation of antibiotic resistance to Gramnegative bacilli isolated from clinics was great serious, and we should pay constant attention to variation of these bacteria of antibiotic-resistance in our responsible region, and to guide doctors using antibiotics reasonably.
出处
《中国微生态学杂志》
CAS
CSCD
2006年第3期229-231,共3页
Chinese Journal of Microecology
关键词
革兰阴性杆菌
耐药谱
变迁
Gram-negative bacilli
Antibiotic-resistance spectra
Variation
