摘要
建立了一种恒温高压氧药物稳定性加速试验方法,用这种方法可在较短的时间内求得药物氧化反应的动力学参数.以10%维生素C溶液为例,维生素C在有氧和无氧条件下均可降解,总的降解速率常数kt由两部分构成:kt=kan+kae,kan为无氧降解速率常数,可表达为kan=Aan?exp(-Ea,an/RT);kae为有氧降解速率常数,可表达为kae=Aae?exp(-Ea,ae/RT)?pO2.
An isothermal experiment with high pressure oxygen was established. The stability of 10% vitamin C solution as a model drug was studied and the kinetics parameters were obtained in a short time with the newly established experimental method. Because vitamin C degrades in both anaerobic and aerobic conditions, the total rate constant kt can be expressed as： kt =kan＋kae, where kan and kac are the anaerobic and aerobic degradation rate constants, respectively. The kan can be expressed as kan=Aan·exp（-Ea,an/RT） according to Arrhenius equation, and the kae was found to be kae=Aac·exp（-Ea,ac/RT）·Po2 in our experiments.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
2006年第11期1189-1194,共6页
Acta Chimica Sinica
基金
国家自然科学基金(No.30472104)资助项目.
关键词
恒温高压氧加速试验
药物稳定性
降解动力学
氧
维生素C
isothermal experiment with high pressure oxygen
drug stability
degradation kinetics
oxygen
vitamin C
