摘要
原发性胆囊癌的发生、发展、转移及预后转归主要涉及ras、myc、c-erbB2等癌基因和p53、p16、p27、DPC4等抑癌基因的突变。ras基因与肿瘤的分化程度负相关,有助于判断预后;c-myc基因的激活表达与胆囊癌的形成、发展和淋巴结转移有关,可反映胆囊癌侵袭性并为早期诊断和治疗提供参考;c-erbB2的表达与胆囊癌的分化程度和预后有关。p53的突变与胆囊癌的发生密切相关,胆汁标本p53基因检测可充分利用所获得的胆汁材料,取得更可靠的诊断结果;p16基因可提高胆囊癌早期诊断率,对估计胆囊癌患者的生存时间有十分重要的意义;p27kip1可为胆囊癌预后不良的标志。
The primary Gallbladder Carcinoma about its genesis, development, metastase and prognosis is mainly related to mutation of some aneogenes such as ras,myc and c-erbB2 and some anti-oncogenes such as p53,p16,p27, DPC4. Ras gene is negative correlated to the differentiation degree of gallbladder and is helpful to the judgement of its prognosis. Activation of C-myc played an important role in the gallbladder carcinogenesis, progression and lymph node metastasis. Examination of C-myc could image the progressional ability and be a marker for early diagnosis and therapy. Expression of e-crbB2 was associated with differentiation and prognosis of gallbladder carcinoma. Mutation of p53 was nearly associated with gallbladder carcinoma. Detection of mutation in p53 gene in bile would give more specificity and be a more valuable diagnosis modality. Examination of p16 gent may improve the rate of early dianosis of gallbladder carcinoma, and was useful to estimate the survival time. Detection of p27^kipl was a marker of poor prognosis of gallbladder carcinoma.
出处
《医学综述》
2006年第11期674-677,共4页
Medical Recapitulate
关键词
胆囊肿瘤
癌基因
抑癌基因
基因诊断
Primary
gallbladder tumor
Oncogene
Anti-oneogene
Gene diagnosis
