摘要
目的探讨血液生化和肝纤维化指标在非酒精性脂肪肝患者临床诊断中的意义。方法对符合B超诊断的286例非酒精性脂肪肝患者进行血液生化指标(TG、TC、HDL-c、ALT、AST、LDL-c、ALT、AST、GGT、ALP)和肝纤维化指标(PCⅢ、HA、CIV、LN)检测,并以体检健康者作为对照。结果非酒精性脂肪肝患者TG和TC水平均高于健康对照组(P<0.01),HDL-c和LDL-c与对照组相比分别呈下降和升高的趋势;重度非酒精性脂肪肝组ALT、AST和GGT明显升高(P<0.01),ALP升高不显著(P>0·05),PCⅢ、HA、CIV、LN均高于健康组(P<0.05),重度组与轻、中度组之间PCⅢ、HA,,CIV和LN差异均有显著性(P<0.01),中度脂肪肝与轻度脂肪肝之间PCⅢ、HA、CIV和LN差异无显著性(P>0·05)。结论非酒性脂肪肝患者多项血液生化指标异常,重度非酒性脂肪肝患者尚存在不同程度的肝纤维化趋向。多项血液生化指标的检测可作为非酒精性脂肪肝筛查的重要依据,而肝纤维化指标的检测可进一步作为非酒精性脂肪肝病情监控和疗效评估的重要依据。
Objective To assess the clinical significance of serum biochemistry and liver fibrosis indexes in the patients with nonalcoholic fatty liver disease. Methods Biochemistry indexes（TG, TG, HDL- c, LDL-c, ALT, AST, GGT and ALP）, and liver fibrosis indexes（ PCⅢ, HA, CⅣ and LN） in 286 patients with nonalcoholic fatty liver disease diagnosed with B ultrasonic echography were determined, and 100 normal volunteers were taken as control. Results The levels of serum TG and TC in the patients with nonalcoholic fatty liver disease were much higher than those in the control （P 〈 0.01 ）. The level of serum HDL- c was increased, but LDL- c level was decreased in the patients with nonalcoholic fatty liver disease. The levels of serum ALT, AST and GGT in severe fatty liver cases were significantly raised （ P 〈 0.01 ） and the level of serum ALP were not raised. Serum levels of PC Ⅲ , HA, CⅣ and LN in the patients with nonalcoholic fatty liver disease were significantly higher than those of healthy subjects （ P 〈 0.05）. the differences of PC Ⅲ, HA, CⅣ and LN between the patients with severe and moderate or mild fatty liver disease were significant （P 〈 0.01 ）. But the difference of PC Ⅲ , HA, C Ⅳ and LN between the patients with mild and moderate fatty liver disease was not significant （P 〉 0.05）. Conclusion Multiple biochemical indexes were abnormal in the patients with nonalcoholic fatty liver disease, and the patients with severe nonalcoholic fatty liver disease has a trend of liver fibrosis. Determination of multiple biochemical indexes could provide a useful tool for screening nonalcoholic fatty liver disease. Moreover, the detection of liver fibrosis indexes may be helpful for monitoring and assessing curative effect in treat ment of the disease.
出处
《中国热带医学》
CAS
2006年第6期960-961,共2页
China Tropical Medicine
关键词
非酒性脂肪肝
血液生化指标
肝纤维化指标
Nonalcoholic fatty liver disease
Biochemical indexes
Liver fibrosis indexes
