摘要
目的研究上皮性卵巢癌组织中E-钙黏附素(E-cadherin)、β-连环蛋白(β-catenin)表达情况,探讨其表达与上皮性卵巢癌生物学行为的关系.方法应用免疫组化方法,检测38例正常卵巢组织和80例上皮性卵巢癌组织中E-cadher-in及β-catenin蛋白表达的情况,并结合卵巢癌的病理分级、淋巴结转移情况和临床分期对其表达进行分类和统计分析.结果相对于正常卵巢组织,E-cadherin在上皮性卵巢癌组织中表达明显降低(P<0.05),且随细胞分化程度降低而减少(P<0.05),随临床分期的增加而降低(P<0.05),伴有区域性淋巴结转移者,E-cadherin表达明显降低(P<0.05);β-catenin在上皮性卵巢癌组织中表达明显增高(P<0.05),其表达量随临床分期的增加而增加(P<0.05),伴有区域性淋巴结转移者其表达增高(P<0.05),与细胞分化程度无关(P>0.05).结论E-cadherin的表达降低及β-catenin的表达增高与上皮性卵巢癌的生物学行为密切相关;两者在上皮性卵巢癌组织中的表达呈负相关;E-cadherin及β-catenin表达水平的高低可作为判断上皮性卵巢恶性肿瘤患者预后的指标.
AIM： To evaluate the relationship between the expressions of E-cadherin, β-eatenin and the biologic behavior of primary epithelial ovarian carcinomas. METHODS： The levels of E-cadherin and β-catenin expressions were examined in 30 cases of normal ovarian tissue and 80 cases of primary epithelial ovarian carcinomas by immunohistochemical technique , and the expressions was classified and analyzed statistically according to pathological grading, lymphatic metastasis and clinical staging. RESULTS： In comparison with the normal ovarian tissue, the expression of E-eadherin was significantly decreased in the poorly differentiated tumor and in the advanced patients （ P 〈 0.05 ）, and also in the tumor tissues from the patients with local lymphnode metastases （P 〈 0.05 ）. On the contrary, the expression of β- catenin was significantly increased in all kinds of primary epithelial ovarian carcinomas （ P 〈 0.05 ） , and it was upregulated along with the progressing of clinical stage （ P 〈 0.05 ） ; it was the same in the tumor tissues from the patients with local lymphnode metastases （ P 〈 0. 05 ）, but no differences were found in relation to cell differentiation （ P 〉 0.05 ）. CONCLUSION ： The downregulation of E-cadherin and the upregulation of β-catenin are correlated with the malignant behavior of primary epithelial ovarian carcinoma, and the examination of E-cadherin and [3-catenin expression in primary epithelial ovarian carcinoma can help to evaluate its clinical prognosis.
出处
《第四军医大学学报》
北大核心
2006年第10期923-926,共4页
Journal of the Fourth Military Medical University
