摘要
目的评价长期家庭氧疗对慢性阻塞性肺疾病（COPD）合并慢性肺源性心脏病（简称肺心病）患者肺动脉高压及高黏血症的影响。方法将55例COPD合并慢性肺心病及高黏血症患者随机分为两组：长期家庭氧疗组（LTDOT组，27例）和对照组（28例）。两组患者均接受常规治疗，LTDOT组用双侧鼻导管家庭给氧，吸氧流量1～3L／min，每天吸氧时间15h以上。分别观察LTDOT组及对照组治疗前、治疗后6个月和1年血常规、血液流变学、超声心动图变化。结果LTDOT组治疗1年后血液黏度较治疗前和治疗6个月时明显下降（P〈0．05），收缩期肺动脉压也较治疗前明显下降（P〈0．05），但血红蛋白、红细胞计数及红细胞压积与治疗前比较无显著差异（P〉0．05）。对照组治疗前、治疗后6个月和1年上述指标比较无显著性差异（P〉0．05）。结论长期家庭氧疗可明显改善COPD合并肺心病患者的血液黏度，降低肺动脉压，减轻右心室负荷，值得临床推广应用。
Objective To evaluate the effects of long term domiciliary oxygen therapy （LTDOT）on pulmonary artery hypertension and hyperviscosity in patients with chronic cot pulmonale caused by chronic obstructive pulmonary disease （COPD） .Methods 55 patients with COPD complicated with cot pulmonale and hyperviscosity were randomly divided into LTDOT group （ n = 27） and control group （ n = 28）. Both two groups were given routine treatment and the LTDOT group were given oxygen supplement more than 15 hours a day （ 02 flow rate of 1-3L/min）. Changes of the hemotology, blood viscosity and pulmonary arterial pressure afte six and twelve months were measured. Results In the LTDOT group, the blood viscosity decreased significantly after one year compared with baseline and 6 months after therapy （ both P 〈 0.05 ） while the systolic pulmonary arterial pressure decreased significantly after one year compared with baseline （ P 〈 0.05）. The levels of hemoglobin and red blood cell count had no significant changes compared with baseline （ P 〉 0.05 ） in the LTDOT group. Meanwhile, there were no significant changes of above parameters in the control group （ P 〉 0.05）. Conclusion Long term domiciliary oxygen therapy can decrease the blood viscosity and pulmonary arterial pressure, and attenuate the right ventricular load of patients with COPD.
出处
《中国呼吸与危重监护杂志》
CAS
2006年第3期185-188,共4页
Chinese Journal of Respiratory and Critical Care Medicine
关键词
长期家庭氧疗
慢性阻塞性肺疾病
慢性肺源性心脏病
肺动脉压
血液黏度
Long term domiciliary oxygen therapy
Chronic obstructive pulmonary disease
Chronic cor pulmouale
Pulmonary arterial pressure
Blood viscosity
