摘要
目的 通过对进行性肌营养不良的临床综合分析，探讨该病的早期诊断方法，减少误诊。方法 对患者进行血清肌酸磷酸激酶（CPK）、肌电图、肝功能和活体组织检查。结果 CPK升高1250～3485U／L，伴丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、乳酸脱氢酶（LDH）升高。肌电图显示在左胫前肌、股四头肌、右腓肠肌静息时有纤颤渡和正相波，提示为肌源性损害肌电图。患者行活体组织检查，病理发现肌纤维肿胀、细胞核增大居中和数目增多、肌纤维减少、纤维之间大量脂肪沉积和结缔组织。结论 检测CPK、肌电图，活体组织检查有助于早期诊断进行性肌营养不良。
Objective To make a correct diagnosis in the early stage and avoid misdiagnosis, we analysed clinical data of patients with Duchenne type muscular dystrophy （DMD）. Methods We analysed serum crieatine phosphokinase（ CPK）, alanine aminotransferase （ ALT）, aspartare aminotransferase （AST）, lactic dehydrogenase （LDH）, electromyogram and muscle biopsy data. Results In DMD patients , serum CPK （ 1 250 ～ 3 485 U/L） , ALT, AST and LDH level were increased above normal range. Electromyogram showed that there were fibrillation waves and sine waves on left tibialis anterior, quadriceps fermoris muscle and right gastrocnemius muscule in static state, suggesting damage of muscular origin. Microscopical examination results of muscle biopsy specemins as follows： There were muscle fiber swelling, karyomegaly was situated in the center of the cell., the number of nucleuses increased, the number of muscle fibers reduced, there was large quantity of lipid and connective tissue deposit between muscle fibers. Conclusions A detailed analysis found CPK, electromyogram and muscle biopsy may help clinicians to make an early diagnosis and avoid misdiagnosis.
出处
《临床和实验医学杂志》
2006年第5期473-474,共2页
Journal of Clinical and Experimental Medicine
关键词
进行性肌营养不良
误诊
病毒性肝炎
Duchenne muscular dystrophy （DMD）
Misdiagnosis
Virus hepatitis
