摘要
目的 探讨小剂量尿激酶静脉溶栓治疗（发病6～72h内）急性脑梗死疗效和安全性。方法 将72例急性脑梗死患者随机分为尿激酶组和对照组，尿激酶组在对照组用药的基础上，给予尿激酶50万U加入生理盐水50ml静滴，30min滴完，连用3d。结果 小剂量尿激酶治疗急性脑梗死疗效明显，与对照组比较有显著差异，溶栓后各时间点与溶栓前比较部分凝血酶原时间（APTT）、凝血酶时间（PT）、纤维蛋白（FIB）无显著差异（P〈0．105）；未见不良反应。结论 发病6～72h的急性脑梗死患者采用小剂量尿激酶溶栓治疗安全、有效。
Objective To study the therapeutic effects and safety of intravenous thmmbolytic therapy with low - dose urokinase （UK） during the first 6 - 72 hours after the onset of acute cerebral infarction （ACI）, Methods Seventy - two patients with ACI were randomly assigned to receive UK plus conventional treatment or conventional treatment only（ control group）, UK 500 000 U diluted in normal saline 50 ml were infused intravenously in 30 minutes once daily for 3 days. Results The therapeutic efficacy of UK group patients were significantly better than that of control group, there were no significant differences in activated partial thromboplastin time （AFIT）, prothrombin time（PT） and fibrinogen（FIB） levels between the 2 groups（ P 〈 0.105）. No adverse reaction was observed. Conclusion Low - dose UK thrombolytic therapy used within the first 6 - 72 hours after the onset of ACI is effective and safe.
出处
《临床和实验医学杂志》
2006年第5期469-470,共2页
Journal of Clinical and Experimental Medicine
