摘要
目的 探讨不同糖耐量者胰岛β细胞功能与甘油三酯、游离脂肪酸等血脂间的关系。方法 研究对象测定血糖、胰岛素、血清甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL—C）及游离脂肪酸（FFA）等。选取年龄在30～80岁之间且既往无糖尿病史者共251例。按1999年WHO的糖尿病诊断标准将研究对象分成新发糖尿病组（DM组）、糖耐量异常组（IGR组）和正常对照组（NGT组）。结果 校正年龄和BMI后，NGT组、IGR组、DM组的Homa—β和葡萄糖处置指数（DI）依次减低，两两比较差别具有统计学意义（P〈0．01）；与NGT组比较，IGR组和DM组的TG、FFA水平增高有统计学意义（P（0．05）。相关分析显示DI指数与TG、FFA呈负相关（P〈0．05）。结论 T2DM和IGR人群均存在血清TG和FFA水平增加和胰岛β细胞功能减退；血清TG和FFA水平越高，胰岛β细胞功能减退越明显，前者与胰岛β细胞功呈轻度负相关。
Objective To study the association of the beta-cell function and serum lipid levels in individuals with different glucose tolerance. Methods The measurements of blood glucose, insulin, fasting serum triglyceride（TG）, total cholesterol（TC）, high density lipoprotein cholesterol（HDL-C）, low density lipoprotein（LDL-c） and free fatty acid（FFA） were assayed. Data of 251 subjects aged between 30 and 80 years without diabetes history were gathered for analysis. These 251 individuals were divided into three subgroups as follows：newly diagnosed type 2 diabetes mellitus（DM）, impaired glucose regulation（IGR） and normal glucose tolerance（NGT） according to the diagnosis standard by WHO in 1999. Results After adjusting with age and BMI, Homa-β and desposition index（DI） of NGT, IGT and DM group were decreased in order（P〈0.01 ）. Compared with NGT group, TG and FFA of IGR and DM group were significantly increased （P〈 0.05 ）. DI was correlated with TG and FFA negatively（P〈 0.05）. Conclusion Both patients with newly diagnosed type 2 diabetes and impaired glucose regulation subjects are existed impaired beta-cell function and high serum TG, FFA levels. The beta-cell function is correlated with serum TG and FFA levels.
出处
《重庆医学》
CAS
CSCD
2006年第9期775-777,共3页
Chongqing medicine
基金
重庆市卫生局医学科学基金资助项目(2000-2027)
2004年重庆市科委攻关项目(2004)
关键词
糖尿病
胰岛Β细胞功能
血脂
diabetes mellitus
beta-cell function
serum lipid
