摘要
肠道菌群的代谢流程与宿主的代谢流程存在交汇与互补的情况,即交互式代谢(metabolicexchange)和共同代谢(co_metabolism)。这种相互作用与许多人类疾病的发生、发展有着重要联系,但我们现在对此却知之甚少。由于这种代谢上的关联,肠道菌群对药物在宿主体内的吸收、代谢、毒理存在显著影响。这提示我们在设计个性化医疗时需充分考虑个体间肠道菌群的差异性。
The mammalian gut microbiota interact extensively with the host through metabolic exchange and cometabolism of substrates. Such metabolome-metabolome interactions are poorly understood, but might be implicated in the aetiology of many human diseases. In this review, we assess the importance of the gut microbiota in influencing the disposition, fate and toxicity of drugs in the host, and conclude that appropriate consideration of individual human gut microbial activities will be a necessary part of future personalized health-care paraditgms.
出处
《国际流行病学传染病学杂志》
CAS
2006年第2期86-89,共4页
International Journal of Epidemiology and Infectious Disease
基金
国家重点基础研究发展计划(973计划)(2003CB515506)
关键词
肠杆菌科
代谢
医疗个性化
Enterobacteriaceae
Metabolism
Personal health care
