摘要
人类T淋巴细胞白血病病毒Ⅰ型(HTLV-1)感染比较少见,主要流行于日本、加勒比海地区、中非和南美洲。已知感染者主要眼部表现包括成人T细胞白血病(ATL)患者的眼部恶性浸润、视网膜变性、眼部神经病变,HTLV-1相关性脊髓病/热带痉挛性瘫痪(HAM/TSP)患者的干燥性角结膜炎及HTLV-1葡萄膜炎(HU)等。HTLV-1相关性眼部病变的范围正在扩大,病程中可能出现免疫调节失常引起的眼部病变或眼部肿瘤,遗传和环境因素可能在不同人群中HTLV-1患者的眼部表现起一定作用。本文就HTLV-1相关眼部表现及最新进展作一综述。
Human T-cell lymphotropic virus type 1 （HTLV-1） infection is endemic in Japan, the Caribbean islands and parts of Central Africa and South America. Known ophthalmic manifestations of HTLV-1 include malignant infiltrates in patients with adult T-cell leukemia/lymphoma （ATL）, retinal degeneration, neuroophthalmic disorders, and keratocon junctivitis sicca in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis （HAM/TSP）, and HTLV-1- associated uveitis （HU）. The spectrum of ocular disease related to HTLVol continues to expand. Routine evaluation of HTLV-1-infected patients is important because immune-mediated or neoplastic ocular involvement may occur during the disease course. Genetic and environmental factors may play a role in the ocular manifestation of HTLV-1 in different populations. This paper reviewed the ocular manifestation and recent development of HTLV-1 infection.
出处
《国际眼科杂志》
CAS
2006年第2期456-459,共4页
International Eye Science
