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药物治疗Graves'病二年患者血清中TSI和CD_8变化的相关性

CORRELATION OF CHANGES OF CD8 AND TSI IN SERA OF GRAVES DIS'EASE PATIENTS TREATED WITH ANTITHYROID DRUG FOR TWO YEARS
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摘要 连续观察他巴唑治疗18~24个月的15例Graves'病患者治疗前、后不同时期TSI,TGI,CD_3,CD_4及CD_8的变化,并以32例正常人作对照。发现治疗前TSI阳性率73.3%,TGI阳性率40%,CD_3,CD_8较对照明显下降,CD_4/CD_8比值明显升高(P<0.005);同一批病人治疗6周后,血清激素水平恢复正常,而TSI,TGI阳性率未见改变,CD_3,CD_8,CD_4/CD_8值未见明显改变[1];治疗24个月以后,除2例出现复发倾向外,余TSI,TGI均恢复正常,阳性率为0,CD_8,CD_4/CD_8亦恢复正常而CD_3仍未恢复正常(P<0.005)。在此治疗过程中TSI与CD_8有明显的负相关性(r=-0.854P<0.05)。证实了体液免疫和细胞免疫的恢复是一个漫长的过程,因此Graves'病患者应长期坚持规律的抗甲状腺药物治疗。 Changes of TSI,CD3,CD4 and CD8 in15 patiants with Grares ; disease at different stages before and 18~24 months after methimazole therapy were observed successively,using 32 normal as control.Positive rates of TSI and TGI before therapy were 73.3% and 40% respectively,CD3 and CD8 decreased significantly compared with control,CD4/CD8 increased significantly(p<0. 005).Hormone levels in sera of the same group patients returned to normal after 6 weeks therapy.Nevertheless,positive rates of TSI and TGI did not change.CD3, CD8, CD4/CD8 did not change significantly. However,24 months after therapy,TSI and TGI reconered to normal,positive rates were 0,except 2 patients relapsed,CD8,CD4/CD8 recovered to normal too.But CD3 did not recover to normal though it increased from 50. 34 to 58.13(p<0. 005).Significant negative correlation between TSI and CD8(r=-0. 854,p<0. 05)was found during the therapy period.It demonstrates that the recovery of humoral immunity and cellular immunity needs a long time.Thus,Graves'desease patients should insist on taking antithyroid drug regularly till the immune indexes return to normal.
出处 《天津医科大学学报》 1996年第1期8-11,共4页 Journal of Tianjin Medical University
关键词 突眼性甲状腺肿 药物疗法 免疫球蛋白 TSI CD8 Graves'disease,TSI,TGI,Lymphocyte subsets,Antithyroid drug
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