摘要
以鼠甲状腺细胞株（ＦＲＴＬ－５）为靶细胞，３Ｈ－ＴｄＲ掺入为生长指标和ｃＡＭＰ产生量为功能指标，对８６例自身免疫性甲状腺病（ＡＩＴＤ）甲状腺生长刺激抗体（ＴＧＡｂ）及部分患者甲状腺功能刺激抗体（ＴｓＡｂ）活性进行了测定。甲状腺Ⅱ°和Ⅲ°肿大的活动性Ｇｒａｖｅｓ病（ＧＤ）的ＴＧＡｂ阳性率为６４％，而Ⅰ°者为２１％。ＧＤ的ＴＧＡｂ与ＴｓＡｂ括性及Ｔ３值不相关。散发性甲状腺肿大患者ＴＧＡｂ阳性率为３１％（５／１６）。提示ＧＤ申状腺肿大与患者体内存在的能使甲状腺细胞增生的ＴＧＡｂ有关。散发性甲状腺肿大患者体内存在自身免疫性紊乱。
We used a strain of functional rat thyroid cells in continuous culture (the
FRTL-5 strain)and H-thymidine incorporation intoDNA as a simple measure of FRTL-5 cells
growth to detect the presence of growth-promoting antibodies (TGAb) in serum samplesfrom 86
patients with autoimmune thyroid disease (AITD).We also detected in some serum samples the
presence of thyroid-stimu-lating antibodies(TSAb)by its ability to increase the cAMP
concentration, The results showed that TGAb was positive in 64%ofpatients with Ⅱ°and Ⅲ°
goitrous Graves′ disease(GD),whereas TGAb was positive in 21%of patients with Ⅰ°goitrous
GD.TGAblevels showed no correlation with either TSAb or T3 levels,In sporadic nontoxic goitres
TGAb was positive in 31%patients. These findings suggest that the formation of GD goitres can
be ascribed to the existence of TGAb.Disturbance of the autoimmunestatus exists in patients
with sporadic nontoxic goitre.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1994年第1期25-27,共3页
Chinese Journal of Endocrinology and Metabolism
关键词
甲亢
甲状腺疾病
生长刺激抗体
Autoimmune thyroid disease growth-promoting antibody
Thyroid-stimulating antibody
