摘要
目的:观察胰腺实性假乳头状肿瘤临床病理学特点,探讨其生物学行为。方法:对3例胰腺实性假乳头状肿瘤临床病理资料进行回顾性复习,并采用免疫组化EnVision法检测肿瘤细胞a-AT、Vim、Syn、EMA、CK、ER、PR的表达。结果:3例SPTP均为女性,平均年龄28岁,瘤体较大,平均9.9cm。组织形态学显示瘤细胞大小一致,排列成实性片块区与假乳头结构,本组有1例组织形态学特殊性表现在瘤细胞胞浆明显空泡变性,呈印戒样细胞,细胞核伴有轻度异形性,粘液染色阴性,浸润包膜及周围胰腺组织,随访4年,患者无复发或转移。免疫组化检查,a-AT阳性(2/3),Vim阳性(3/3),Syn阳性(1/3),EMA阴性(0/3),CK弱阳性(1/3),ER阴性(0/3),PR阳性(1/3)。结论:胰腺实性假乳头状肿瘤好发于年轻女性,具有低度恶性潜能的肿瘤,免疫组化对胰腺实性假乳头状肿瘤的诊断和鉴别诊断具有较重要的价值。
Objective： To study the clinicopathologic characteristics and histogenesis of solid-pseudopapillary tumor （SPT） of the pancrea. Methods： The clinicopathologic data were reviewed in there patients with STP. Immunohistochemistry for a-AT,Vim ,Syn ,EMA ,CK ,ER ,PR was performed in all the case using EnVision method. Results： All the patients were adolescent and young adult female, mean 28 years. The mean diameter of tumor was 9.6cm,all encapsulated.Histologic examination showed presence of solid sheets, pseudopapillary, in all of the cases. Hemorrhage, foam cell, 2 cases were positive for a-AT, 3 cases expressed vimentin ,1 case expressed Syn and PR.But negative for ER and EMA. Conclusion： SPT of pancreas is a distinct Clinicopathologic entity in young adult female patients relertivty and that is a tumor with low malignant potential. Immunohistochemistry is very important in the diagnosis and differential diagnosis of SPT of the pancrea.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2006年第8期442-444,共3页
Chinese Journal of Clinical Oncology
基金
江西省科技厅重点基金项目(编号:20033063)
江西省卫生厅科技计划基金项目资助(编号:20043098)
关键词
胰腺肿瘤
实性假乳头状肿瘤
免疫组化
Pancreatic tumor Solid-pseudopapillary of the pancrea Immunohistochemistry
